endstream endobj startxref 0000001424 00000 n 0000009418 00000 n h��Zmo��+��{| �(N4ia�M��~P��#@��\����3���Nc�m�������J� q��/2�_�0H�q|H.C��R�R��+y�~��s@���(A����K����C-���) �|�9y�`��������bx�9y��_��\\^�@�/'OOnΗ�!�{��������my��|v�À�m�\n�.���cL�����7�/Ϯ6�=���ɰ�}��|���v��ϻ/Nwg����l�6�����zVk��$���^}��|��n��,9��dۦ�Xǚ|ry�����ݐ��O?��yz�}5eW��h?q�1�F�ݧ4J�Af[���j�dG����^n7z}~yq���NϮ�����B�n��ή.ϟ\���ns�۾�Z;ג���W���&���-���g�NN�܁ʳ�o��Ϸ�[�����r�����������̓'7?lnN_�zu�}II8�������Wg�6ˢ#VhlvdK8�L�=�o'7���� 0000010987 00000 n In male rats, there was increased mineralization of the renal papilla at all exposure concentrations. 0000004737 00000 n Inhalation of vapors is the most likely route of exposure in the work place. �k��j�ŞK�������ϼ8 )ӣOΊ*4�.s�,CU�T¬_%r�8O"4Ψ��V�8���y���!�f����|�/=c�l �5�p ����*q�����f�Cp�T���薚��v�:�p�46��B&f���x��X$)�VҬ�М ��0�'�Lc�W� �S�I��֭� ~�T����=���{���9 Survival was decreased in male rats at 1800 ppm. 68 0 obj <>stream Hepatocellular adenomas, and adenoma or carcinoma (combined) were increased in male and female mice exposed to 1800 ppm. 0000007876 00000 n Methyl isobutyl ketone CAS RN: 108-10-1 Storage Conditions. 29 0 obj<> endobj We use cookies to help provide and enhance our service and tailor content and ads. MAY FORM EXPLOSIVE PEROXIDES IN AIR. 0000001794 00000 n 0000006329 00000 n The incidence of chronic progressive nephropathy (CPN) was increased at 1800 ppm and the severity was increased in all exposed groups. 0000001603 00000 n �`���⃨��e1�|*0I�'�e�1��f�4�,a�)���`���m��A��F�+U�ut)@������zt%�^� �`jdT�X 0000008686 00000 n 0000003973 00000 n endstream endobj 30 0 obj<. trailer 51 0 obj <>/Filter/FlateDecode/ID[<31346B5560A2D34D9FB31D8E5A592020><67A77A2069B32D46BC0A944AF1F9F267>]/Index[31 38]/Info 30 0 R/Length 92/Prev 94310/Root 32 0 R/Size 69/Type/XRef/W[1 2 1]>>stream 0000003690 00000 n AFFECTS CENTRAL NERVOUS SYSTEM, LIVER … Store at Room Temperature. 0000004475 00000 n Methyl isobutyl ketone is also used in industrial extraction processes, as a solvent for protective coatings and in rare metals extraction and in dewaxing of mineral oils, in drycleaning preparations and in the synthesis of methyl isobutyl carbinol. - [4-Methyl-2-pentanone ; Methylisobutyl ketone, MIBK]:100ppm 410mg/m3 B. xref 0000003734 00000 n (4) Cancer Risk: No information is available on the carcinogenic effects of methyl isobutyl ketone in humans or animals. Methyl isobutyl ketone (MIBK) is primarily used as a denaturant for rubbing alcohol, as a solvent and in the manufacture of methyl amyl alcohol. h�b```"SVi&~�g`��0p4�9�8��!Y�`�D�%��}�������Lj �0�@E|���@Z��������-�8!��P�������uBp�����l�鎧u�_��g����� w�c^D�Q The primary targets of MIBK toxicity and carcinogenicity were the kidney in rats and the liver in mice. 0000004813 00000 n HARMFUL IF INHALED. 0000034054 00000 n In order to evaluate the potential of MIBK to induce toxic and carcinogenic effects following chronic exposure, groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MIBK at concentrations of 0, 450, 900, or 1800 ppm by inhalation, 6 h/day, 5 days per week for 2 years. %PDF-1.5 %���� (4) EPA has classified methyl isobutyl ketone as a Group D, not classifiable as to human carcinogenicity. 0000001344 00000 n Safety Data Sheet >. %%EOF in rats and mice exposed to methyl isobutyl ketone by inhalation. Hazards Identification Emergency Overview ----- DANGER! The relationship of these tumors to exposure to MIBK was uncertain. 0000053428 00000 n endstream endobj 32 0 obj <> endobj 33 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>> endobj 34 0 obj <>stream EPA/635/R-03/002 TOXICOLOGICAL REVIEW OF METHYL ISOBUTYL KETONE (CAS No. 0 0 0000007113 00000 n Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure, https://doi.org/10.1016/j.tox.2007.11.014. Keep container tightly closed in a dry and well-ventilated place. 108-10-1) In Support of Summary Information on the Integrated Risk Information System (IRIS) Methyl isobutyl ketone (MIBK) CASRN 108-10-1 | DTXSID5021889.