Please enable it to take advantage of the complete set of features! 226-237 (in Italian). J Appl Toxicol. Natl Toxicol Program Tech Rep Ser. Get the latest public health information from CDC: This site needs JavaScript to work properly. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 500 ppm. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: 2006 Nov;(534):1-290. 1946]. Short-term and subchronic inhalation exposures (as low as 100 ppm) produced effects in the kidney and liver that were species and sex dependent. Reproductive Toxicity Risk Assessment (U.S. EPA, 1996), Guidelines for Neurotoxicity Risk ... acetone, isobutyl methyl ketone, 4-methyl-2-oxopentane, hexone, and hexanone (HSDB, 2000). Linari F, Pernell G, Varese D [1964]. Methyl isobutyl ketone (MIBK) is the organic compound with the formula (CH 3) 2 CHCH 2 C(O)CH 3. Safety assessment of MIBK (methyl isobutyl ketone). In: Hygienic guide series. 2004;23 Suppl 1:29-57. doi: 10.1080/10915810490274298. Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of methyl isobutyl ketone in male F344/N rats based on increased incidences of renal tubule neoplasms. 1964]. Please enable it to take advantage of the complete set of features! In clinical tests, most of the absorbed MIBK had been eliminated from the body 90 min post exposure. Keywords CAS 108-10-1, Inhalation, Methyl Isobutyl Ketone (MIBK), Rat, Reproductive Toxicity, Two-Generation Methyl isobutyl ketone (MIBK: 2-methyl-4-pentanone, CAS RN 108-10-1) is a clear, flammable liquid (United States En-vironmental Protection Agency [USEPA] 1994) produced for general commercial use as a solvent in lacquers, paints, and var-nishes; in vinyl, epoxy, acrylic, and natural … This colourless liquid, a ketone, is used as a solvent for gums, resins, paints, varnishes, lacquers, and nitrocellulose. Amended final report of the safety assessment of t-Butyl Alcohol as used in cosmetics. Chemical: CAS Number: Beryllium and beryllium compounds: 7440-41-7 (Be) Tert-butyl alcohol: 75-65-0: Ethyl tert-butyl ether: 637-92-3: Methyl isobutyl ketone Methyl isobutyl ketone. 2. Basis for revised IDLH: The revised IDLH for hexone is 500 ppm based on acute inhalation toxicity data in humans [Linari et al. [1963]. A DNA reactive Mode-of-Action (MOA) for this liver tumor response is not supported by the evidence as MIBK and its major metabolites lack … Kawai T, Zhang ZW, Takeuchi A, Miyama Y, Sakamoto K, Higashikawa K, Ikeda M. Int Arch Occup Environ Health. 2003 Feb;76(1):17-23. doi: 10.1007/s00420-002-0374-9. Int J Toxicol. NLM Am Ind Hyg Assoc Q 17(2):129-185. HHS Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. Scand J Work Environ Health. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. uuid:86434afb-f520-40d9-965a-aa80f4964392 -, Int Arch Occup Environ Health.