Many things: Could be factitious or drug or associated with disease process platelet can clump leading to a falsely low count. A platelet count below 10,000 is considered severe thrombocytopenia. Extremely low levels can be life-threatening [ 6 ]. However, in the elderly it is most often as a result from arthritis, a malfunctioning immune system or chemotherapy. What causes low platelet count? To learn more, please visit our. MayoClinic.com explains that the spleen is normally an important infection-fighting and blood filtering organ, but if it becomes enlarged it may trap too many platelets 2. If that doesn't work, stronger medications can be used to suppress … According to Chemo Care, if platelet count becomes low, the blood vessels can leak small amounts of blood 1. Connect by text or video with a U.S. board-certified doctor now â wait time is less than 1 minute! What Are the Causes of Low White Blood Cell Count & Weight Loss? Abnormal levels of these cells can be a sign of illness, disease or complications. In people with bleeding, more info is needed. Platelets and white blood cells are two of the main blood cell types in the body. In simple terms, blood platelets are responsible for thickening blood. A normal platelet count ranges from 150,000 to 400,000 per microliter of blood.